… images of the mouse and human egg zona pellucida (ZP). … contrast) of an unfertilized
mouse egg incubated in the … mutation in exon-3 of ZP1 was identified in an infertile patient …

… Fertility in female mammals, including mice and humans, is dependent on the presence of
a zona pellucida (ZP… Exons subject to mutations that caused infertility are marked by an X. …

BACKGROUND Infertility is a major issue in human reproductive health, affecting an estimated
15% of couples worldwide. Infertility can result from disorders of sex development (DSD) …

… variants in two infertile sisters in a family with a thin zona pellucida (ZP) phenotype. … a
Expression and location of the mutant protein in mouse oocytes. Oocytes microinjected with RNase-…

… A heterozygous missense mutation in exon-3 of hZP1 was identified in an infertile patient …
Harvard Medical School, Roche Institute of Molecular Biology, and Icahn School of Medicine at …

… genetic analysis in the patients with female infertility due to abnormal zona pellucida and …
The mouse zona pellucida is composed of three glycoproteins—mZP1, mZP2, and mZP3. …

… . Targeted disruption of the mZP3 gene results in production of eggs lacking a zona
pellucida and infertility in female mice. Proc Natl Acad Sci USA 1996;93:5431–6.doi:10.1073/pnas.…

… infertile, while the corresponding 236 mutant mice were fertile.The different phenotypes of
the same gene mutation of 237 zona pellucida in human and mouse … 627 Molecular Genetics …

… or ZP gene mutations in humans, can result in female infertility. Further research on the …
results in production of eggs lacking a zona pellucida and infertility in female mice. Proc. Natl. …

… Zp2 null female mice formed a thin ZP and were infertile [6]. Zp3 null female … mutation and
will facilitate the genetic diagnosis of infertile individuals with abnormal ZP and female infertility…